Licensed Casinos
De hoge efficiëntie van Toncoin geeft de mogelijkheid voor tal van interessante use-cases. Een van de belangrijkste is in-app transacties. Ontwikkelaars kunnen Toncoin eenvoudig in hun apps integreren, of het nu gaat om bank apps, sociale media platforms, blockchain-gamingprojecten, NFT marktplaatsen of DeFi protocollen https://gamble-online-aus.org/.
Op dit moment zijn er iets meer dan 3,4 miljard TON coins in omloop, maar de maximale voorraad bedraagt 5 miljard. Een opvallend kenmerk is dat elke validator node minstens 600.000 coins moet bezitten om te kunnen deelnemen. Deze coins worden verzameld door gebruikers die TON willen inzetten, en de beloningen worden verdeeld onder de validators.
TON is een aanzienlijke speler in de cryptowereld, met een marktkapitalisatie van meer dan 6 miljard USD. In december 2021 bereikte de prijs van TON een hoogtepunt van 4,4 USD per coin, maar de markt vertoonde daarna neerwaartse bewegingen. De prijs varieert momenteel tussen 1,5 en 2,5 USD per coin.
Mines ton
So if you’ve ever made and been unimpressed by a Minestrone Soup before – I promise you, this one will not disappoint! (Because I’ve been there too, which is essentially why I ended up just creating my own. 😇)
Awesome recipe! Wonderful explanation of what ingredients to use with the seasons. Loved the slow introduction of vegetables to make a proper broth without having to add a store bought one. Thank you!
It’s hearty, it’s chunky, it comes fully loaded and the savoury tomato soup broth is full of flavour thanks to a few extra little touches that make all the difference: bacon sautéed until golden, a dash of Worcestershire sauce, and the final touch – parmesan stirred in the soup as well as sprinkled on top.
But where to start? Here is a hearty base minestrone soup recipe, with plenty of white beans, zucchini, cabbage, tomatoes, carrots, celery, and onions. It’s one of our favorite soups to make when the weather turns cool.
Minestronesoep. Ik zit de laatste tijd helemaal in de soep-fase en heb vandaag wederom een heel erg lekker soep recept voor je. Namelijk mijn minestronesoep recept. Een heerlijke gevulde Italiaanse maaltijdsoep met heel veel groenten. Absoluut een op en top verwarmend kommetje soep en ook nog eens heel eenvoudig om te maken.
Noxecoin
In 2015, Purdue Pharma’s abuse-resistant OxyNEO and six generic versions of OxyContin had been on the Canada-wide approved list for prescriptions since 2012. In June 2015, then-federal Minister of Health Rona Ambrose announced that within three years, all oxycodone products sold in Canada would need to be tamper-resistant. Some experts warned that the generic product manufacturers may not have the technology to achieve that goal, possibly giving Purdue Pharma a monopoly on this opiate.
Ritonavir or lopinavir/ritonavir greatly increase plasma concentrations of oxycodone in healthy human volunteers due to inhibition of CYP3A4 and CYP2D6. Rifampicin greatly reduces plasma concentrations of oxycodone due to strong induction of CYP3A4. There is also a case report of fosphenytoin, a CYP3A4 inducer, dramatically reducing the analgesic effects of oxycodone in a chronic pain patient. Dosage or medication adjustments may be necessary in each case.
Oxycodone, a semi-synthetic opioid, is a highly selective full agonist of the μ-opioid receptor (MOR). This is the main biological target of the endogenous opioid neuropeptide β-endorphin. Oxycodone has low affinity for the δ-opioid receptor (DOR) and the κ-opioid receptor (KOR), where it is an agonist similarly. After oxycodone binds to the MOR, a G protein-complex is released, which inhibits the release of neurotransmitters by the cell by decreasing the amount of cAMP produced, closing calcium channels, and opening potassium channels. Opioids like oxycodone are thought to produce their analgesic effects via activation of the MOR in the midbrain periaqueductal gray (PAG) and rostral ventromedial medulla (RVM). Conversely, they are thought to produce reward and addiction via activation of the MOR in the mesolimbic reward pathway, including in the ventral tegmental area, nucleus accumbens, and ventral pallidum. Tolerance to the analgesic and rewarding effects of opioids is complex and occurs due to receptor-level tolerance (e.g., MOR downregulation), cellular-level tolerance (e.g., cAMP upregulation), and system-level tolerance (e.g., neural adaptation due to induction of ΔFosB expression).
In August 2010, Purdue Pharma reformulated their long-acting oxycodone line, marketed as OxyContin, using a polymer, Intac, to make the pills more difficult to crush or dissolve in water to reduce non-medical use of OxyContin. Inactive ingredients/excipients are butylated hydroxytoluene (BHT), hypromellose, polyethylene glycol 400, polyethylene oxide, magnesium stearate, and titanium dioxide. The FDA approved relabeling the reformulated version as abuse-resistant in April 2013.
